
Our reviews on pulmonary drug delivery
La chimiothérapie inhalée – Partie 1 : Concept et challenges technologiques actuels
R. Rosière, J. Hureaux, V. Levet, K. Amighi, N. Wauthoz. Revue des Maladies Respiratoires 35(4), 357-377 (2018).
La chimiothérapie inhalée – Partie 2 : Clinique et applications potentielles
R. Rosière, J. Hureaux, V. Levet, K. Amighi, N. Wauthoz. Revue des Maladies Respiratoires 35(4), 357-377 (2018).
Recent developments in inhaled Triazoles against invasive pulmonary aspergillosis
R. Merlos, K. Amighi and N. Wauthoz. Curr Fungal Infect Rep 8(4), 331-342 (2014).
Phospholipids in pulmonary drug delivery
N. Wauthoz and K. Amighi,. Eur. J. Lipid Sci. Technol., 116, 1114–1128 (2014).
Formulation Strategies for Pulmonary Delivery of Poorly Soluble Drugs
N. Wauthoz and K. Amighi,. IN: Pulmonary Drug Delivery, Advances and Challenges, Edit. Wiley 2015, Chapter 5, pp 87-121.
Formulations for intranasal delivery of pharmacological agents to combat brain disease: a new opportunity to tackle GBM?
M. Van Woensel, N. Wauthoz, R. Rosière, K. Amighi, V. Mathieu, F. Lefranc, S. Van Gool, S. De Vleeschouwer, Cancers, 5(3), 1020-1048 (2013).
Inhaled proteins: challenges and perspectives
F. Depreter, G. Pilcer, K. Amighi. Int. J. Pharm., 447(1-2), 251-80 (2013).
Lactose characteristics and the generation of the aerosol
G. Pilcer, N. Wauthoz, K. Amighi,. Adv. Drug. Del. Rev., 64, 233–256 (2012).
Formulation strategy and use of excipients in pulmonary drug delivery
G. Pilcer, K. Amighi. Int. J. Pharm., 392, 1-19 (2010).
Our scientific publications on cisplatin-based DPI
Platinum pharmacokinetics in mice following inhalation of cisplatin dry powders with different release and lung retention properties
V. Levet, R. Merlos, R. Rosière, K. Amighi, N. Wauthoz. Int. J. Pharm., 517, 359-372 (2017).
Development of controlled-release cisplatin dry powders for inhalation against lung cancers
V. Levet, R. Rosière, R. Merlos, L. Fusaro, G. Berger, K. Amighi, N. Wauthoz. Int. J. Pharm., 515, 209-220 (2016).
Our scientific publications on lung cancer cell targeting – Paclitaxel-based DPI
New folate-grafted chitosan derivative to improve delivery of paclitaxel-loaded solid lipid nanoparticles for lung tumor therapy by inhalation
R. Rosière, M. Van Woensel, M. Gelbcke, V. Mathieu, J. Hecq, T. Mathivet, M. Vermeersch, P. Van Antwerpen, K. Amighi, N. Wauthoz. Mol Pharm, 15(3), 899-910 (2018)
Development and evaluation of well-tolerated and tumor penetrating micelle-based dry powders for inhaled anti-cancer chemotherapy
R. Rosière, M. Van Woensel, V. Mathieu, I. Langer, T. Mathivet, M. Vermeersch, K. Amighi and N. Wauthoz. Int. J. Pharm. 501(1-2), 148-159 (2016).
New dry powders for inhalation containing temozolomide-based nanomicelles for improved lung cancer therapy
R. Rosière, M. Gelbcke, V. Mathieu, P. Van Antwerpen, K. Amighi, N. Wauthoz. Int. J. Oncol., 47(3), 1131-42 (2015).
Our scientific publications on DPI delivery in asthma and COPD
Proposed algorithm for healthcare professionals based on product characteristics and in vitro performances in different use conditions using formoterol-based marketed products for inhalation
N. Wauthoz, I. Hennia, B. Dejaeger, S. Ecenarro, K. Amighi. Int. J. Pharm. 530, 415-429 (2017).
Evaluation of the content homogeneity and dispersion properties of fluticasone DPI compositions
T. Sebti, F. Vanderbist and K. Amighi. J. Drug Del. Sc. Technol., 17(3) 223-229 (2007).
Pharmacoscintigraphic evaluation of lipid dry powder budesonide formulations for inhalation
T. Sebti, G. Pilcer, B. Van Gansbeke, S. Goldman, A. Michils, F. Vanderbist and K. Amighi. Eur. J. Pharm. Biopharm., 64, 26-32 (2006).
Our scientific publications on DPI delivery of antibiotics
Carrier-free combination for dry powder inhalation of antibiotics in the treatment of lung infections in cystic fibrosis
G. Pilcer, V. De Bueger K. Traina, H. Traore, T. Sebti, F. Vanderbist, K. Amighi. Int. J. Pharm., 451(1-2), 112-20 (2013).
New co-spray-dried tobramycin nanoparticles-clarithromycin inhaled powder systems for lung infection therapy in cystic fibrosis patients
G. Pilcer, R. Rosière, K. Traina, T. Sebti, F. Vanderbist, K. Amighi. J. Pharm. Science, 102(6), 1836-46 (2013).
Spray-dried carrier-free dry powder tobramycin formulations with improved dispersion properties
G. Pilcer, F. Vanderbist, K. Amighi. J. Pharm. Sci., 98, 1463-1475 (2009).
Preparation and characterization of spray-dried tobramycin powders containing nanoparticles for pulmonary delivery
G. Pilcer, F. Vanderbist, K. Amighi. Int. J. Pharm., 365, 162-169 (2009).
Correlations between cascade impactor analysis and laser diffraction techniques for the determination of the particle size of aerosolised powder formulations
G. Pilcer, F. Vanderbist, K. Amighi. Int. J. Pharm., 358, 75-81 (2008).
Pharmacoscintigraphic and pharmacokinetic evaluation of Tobramycin DPI Formulations in Cystic Fibrosis Patients
G. Pilcer, J. Goole, B. Van Gansbeke, D. Blocklet, Ch. Knoop, F. Vanderbist, K. Amighi. Eur. J. Pharm. Biopharm. 68, 413-421 (2008).
Formulation and characterisation of lipid-coated tobramycin particles for dry powder inhalation
G. Pilcer, T. Sebti and K. Amighi. Pharm. Res. 23(5) 931-940 (2006).
Our scientific publications on DPI delivery of antifungal drugs
Optimization and Scaling-Up of ITZ-based Dry Powders for Inhalation
R. Merlos, N. Wauthoz, V. Levet, L. Belhassan, T. Sebti, F. Vanderbist, K. Amighi. J. Drug Deliv. Sci. Technol., 37, 147-157 (2017).
Pharmacokinetic evaluation in mice of amorphous itraconazole-based dry powder formulations for inhalation with high bioavailability and extended lung retention
C. Duret, N. Wauthoz, R. Merlos, T. Sebti, F. Vanderbist and K. Amighi. Eur. J. Pharm. Biopharm., 86(1): 46-54 (2014).
New Inhalation-Optimized Itraconazole Nanoparticle-Based Dry Powders for the Treatment of Invasive Pulmonary Aspergillosis,
C. Duret, N. Wauthoz, T. Sebti, F. Vanderbist and K. Amighi. Int. J. Nanomedicine 7, 5475–5489 (2012).
New Respirable and Fast Dissolving Itraconazole Dry Powder Composition for the Treatment of Invasive Pulmonary Aspergillosis
C. Duret, N. Wauthoz, T. Sebti, F. Vanderbist and K. Amighi. Pharm. Research, 29, 2845–2859 (2012).
Itraconazole-mannitol solid dispersions for inhalation with enhanced dissolution and dispersion properties
C. Duret, N. Wauthoz, T. Sebti, F. Vanderbist and K. Amighi. Int. J. Pharm., 428(1–2), 103-113 (2012).
In vitro and in vivo evaluation of a dry powders endotracheal insufflator device for use in dose dependent preclinical studies in mice
C. Duret, R. Merlos, N. Wauthoz, J. Goole, C. Maris, I. Rolland, T. Sebti, F. Vanderbist and K. Amighi. Eur. J. Pharm. Biopharm., 81(3), 627-634 (2012).
Our scientific publications on DPI delivery of peptides, proteins and monoclonal antibodies
Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients
F. Depreter, A. Burniat, D. Blocklet, S. Lacroix, M. Cnop, F. Fery, N. Van Aelst, G. Pilcer, M. Deleers, S. Goldman, and K. Amighi. Eur. J. Pharm. Biopharm. 80(1) 4-13 (2012).
Formulation and in vivo evaluation of highly dispersible insulin dry powder formulations for lung administration
F. Depreter, K. Amighi. Eur. J. Pharm. Biopharm., 76 (3), 454-463, (2010).
Our scientific publications on Nose-to-brain delivery
Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia
L. Salade, N. Wauthoz, C. De Vriese, K. Amighi, J. Goole. Int J Nanomed 12, 8531-8543 (2017).
Chitosan-coated liposome dry-powder formulations loaded with ghrelin for nose-to-brain delivery
L. Salade, N. Wauthoz, M. Vermeersch, K. Amighi, J. Goole. Eur. J. Pharm. Biopharm., 129, 257-266 (2018).
Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration
M. Van Woensel, N. Wauthoz, R. Rosière, V. Mathieu, R. Kiss, F. Lefranc, B. Steelant, S. W. Van Gool, T. Mathivet, H. Gerhardt, K. Amighi and S. De Vleeschouwer. J. Control. Rel., 227 (10) 71-81 (2016).
Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy
M. Van Woensel, T. Mathivet, N. Wauthoz, R. Rosière, A.D. Garg Abhishek, P. Agostinis, V. Mathieu, R. Kiss, F. Lefranc, L. Boon, J. Belmans, S.W. Van Gool, H. Gerhardt, K. Amighi, S. De Vleeschouwer. Scientific Reports 7(1), 1217 (2017).
Our scientific publications on New fillers and/or carriers for DPI
Preparation and in vitro evaluation of new lipidic carriers and fillers for inhalation
T. Sebti and K. Amighi. Eur. J. Pharm. Biopharm. 63(1), 51-58 (2006).
Our scientific publications on DPI delivery of other anticancer drugs
Temozolomide-based dry powder formulations for lung tumor-related inhalation treatment
N. Wauthoz, P. Deleuze, A. Saumet, C. Duret, R. Kiss, K. Amighi. Pharm. Res., 28(4) 762-775 (2011).
In vivo assessment of temozolomide local delivery for lung cancer inhalation therapy
N. Wauthoz, P. Deleuze, J. Hecq, I. Roland, I. Adanja, O. Debeir, C. Decaestecker, V. Mathieu, R. Kiss, K. Amighi. Eur. J. Pharm. Science 39, 402-411 (2010).
Scientific international meetings and congresses